体细胞突变作为化学致癌物导致BHK细胞恶性转化的基础。
Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.
作者信息
Bouck N, di Mayorca G
出版信息
Nature. 1976;264(5588):722-7. doi: 10.1038/264722a0.
DOI:10.1038/264722a0
PMID:827710
Abstract
The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.
摘要
BHK细胞中恶性转化的化学诱导似乎源于体细胞突变。稳定的转化体可恢复正常，其频率会因诱变致癌物而显著增加，并且常常表现出温度限制型表型，这表明基因产物发生了改变。
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