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导致突变的生殖细胞相互作用及其检测。

Alteractions of germ cells leading to mutagenesis and their detection.

出版信息

Environ Health Perspect. 1978 Jun;24:105-12. doi: 10.1289/ehp.7824105.

DOI:10.1289/ehp.7824105
PMID:17539136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637227/
Abstract

Germ cell risk is an essential component of estimating the deleterious results of environmental mutagens. The present set of in vivo model systems appears to have limited ability to measure germ cell risk from all types of genetic lesions. The assays most practical for use in genetic testing measure the induction of chromosome alterations but not specific locus gene mutations. Quantitative estimation of germ cell risk based on such available assays is difficult to make and may lead to incorrect assumptions of risk. Better assessment of germ cell genetic damage will require expansion of present procedures to increase sensitivity and the development of improved assay systems.

摘要

生殖细胞风险是评估环境诱变剂有害后果的一个重要组成部分。目前这组体内模型系统似乎没有能力从所有类型的遗传损伤来测量生殖细胞风险。在遗传测试中最实用的测定方法是测量染色体改变的诱导，但不能测量特定基因座基因突变。基于这种可用的测定方法对生殖细胞风险进行定量估计是困难的，并且可能导致对风险的错误假设。更好地评估生殖细胞遗传损伤将需要扩展现有的程序以提高灵敏度，并开发更好的测定系统。

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本文引用的文献

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