Synthesis of 3-aryl-2-thiohydantoin- and 3-arylhydantoin-5-acetic acids and screening of some of their pharmacological properties.
作者信息
Korohoda M J, Bojarska A B, Kleinrok Z, Przegaliński E
出版信息
Pol J Pharmacol Pharm. 1976;28(5):423-7.
PMID:827740
Abstract
Seven 3-aryl-2-thiohydantoin-5-acetic acids were obtained from asparagine and arylisothiocyanates. After desulphuration of these compounds by monochloroacetic acid seven 3-arylhydantoin-5-acetic acids were obtained. The structure of these compounds was confirmed by their IR spectra. None of the compounds neither showed the anticonvulsive activity in the electroconvulsions and pentylenetetrazole tests nor inhibited the prostaglandin synthetase.
摘要
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