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A search for new anticonvulsant compounds among 3-aryl-5-benzylidene derivatives of 2-thiohydantoin.

作者信息

Korohoda M J, Kleinrok Z, Przegaliński E

出版信息

Pol J Pharmacol Pharm. 1976 May-Jun;28(4):329-33.

PMID:981022
Abstract

13 New 3-aryl-5-benzylidene-2-thiohydantoins were obtained by condensation of 3-o-tolyl- and 3-m-tołyl-2--thiohydantoin with aromatic aldehydes. The structure of the obtained compounds was confirmed by IR spectra. Derivatives of 2-thiohydantoin 1-13 show weak anticonvulsant activity in pentetrazole test and show no protecting activity against the maximal electric shock.

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