Lipman R D, Gaillard E T, Harrison D E, Bronson R T
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Lab Anim Sci. 1993 Oct;43(5):439-44.
A retrospective study of the prevalence of amyloidosis in mice from several facilities was done. Amyloid deposition is an age-related lesion. The influence of common laboratory factors on the occurrence of this lesion was analyzed. This study documented genotypic difference in susceptibility to amyloidosis and showed that caging and pathogen status both impact on the number of cases of amyloidosis seen in a population. The lowest percentage of affected mice was seen when the animals were individually caged in a specific pathogen-free facility where conditions of stress were minimized.
对来自多个机构的小鼠淀粉样变性患病率进行了一项回顾性研究。淀粉样沉积是一种与年龄相关的病变。分析了常见实验室因素对该病变发生的影响。这项研究记录了淀粉样变性易感性的基因型差异，并表明饲养环境和病原体状态都会影响群体中淀粉样变性病例的数量。当动物单独饲养在特定的无特定病原体设施中，且应激条件降至最低时，受影响小鼠的比例最低。
