Griffiths A J, Humphreys S M, Clark M L, Fielding B A, Frayn K N
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, University of Oxford, UK.
Am J Clin Nutr. 1994 Jan;59(1):53-9. doi: 10.1093/ajcn/59.1.53.
We tested the hypothesis that when fat is ingested in combination with carbohydrate, direct release of fatty acids into the plasma may occur. Eight normal subjects ingested two meals: high-fat (80 g fat, 80 g carbohydrate, and 18 g protein) and low-fat (< 1 g fat, otherwise closely matched). Over the subsequent 6 h, net fat oxidation was greater after the high-fat meal (20.7 vs 10.6 g, P < 0.01). Plasma nonesterified fatty acid (NEFA) concentrations were markedly suppressed after the low-fat meal, but relatively maintained after the high-fat meal (P < 0.01). The profile of plasma NEFAs changed after the high-fat meal, consistent with entry of meal-derived fatty acids into the NEFA pool. We suggest that after ingestion of combinations of carbohydrate and fat, the action of lipoprotein lipase on chylomicron-triacylglycerol leads to direct release of fatty acids into the plasma and increased fat oxidation.
当脂肪与碳水化合物一起摄入时，脂肪酸可能会直接释放到血浆中。八名正常受试者进食了两餐：高脂餐（80克脂肪、80克碳水化合物和18克蛋白质）和低脂餐（脂肪含量<1克，其他成分与之密切匹配）。在随后的6小时内，高脂餐后的净脂肪氧化量更大（20.7克对10.6克，P<0.01）。低脂餐后血浆非酯化脂肪酸（NEFA）浓度显著降低，但高脂餐后相对保持稳定（P<0.01）。高脂餐后血浆NEFAs的分布发生了变化，这与膳食来源的脂肪酸进入NEFA池一致。我们认为，在摄入碳水化合物和脂肪的组合后，脂蛋白脂肪酶对乳糜微粒三酰甘油的作用导致脂肪酸直接释放到血浆中，并增加脂肪氧化。
