Gaudeau S, Derrida J P, Tillement J P, Vernant P
Arch Mal Coeur Vaiss. 1976 Oct;69(10):1083-8.
The authors report a case of a lady of 45 years of age who presented with a cardiomyopathy with hypothiaminaemia which had been made considerably worse by treatment with imipramine. Once treatment with the antidepressant was stopped, her condition returned to its previous status. The very high plasma imipramine level recorded in his case is undoubtedly the reason for the cardiac toxicity. The mechanism and role of hypothiaminaemia have not far been explained logically.
作者报告了一例45岁女性病例，该患者患有心肌病并伴有低硫胺血症，而丙咪嗪治疗使其病情显著恶化。停用抗抑郁药治疗后，她的病情恢复到之前的状态。该病例中记录的极高血浆丙咪嗪水平无疑是心脏毒性的原因。低硫胺血症的机制和作用尚未得到合理的解释。
