el-Bokle D, Smith S J, Germane N, Sharawy M
Medical College of Georgia, Augusta 30912-1122.
Cleft Palate Craniofac J. 1993 Nov;30(6):542-7. doi: 10.1597/1545-1569_1993_030_0542_ntfcpe_2.3.co_2.
Alveolar bone grafting is an adjunctive procedure that has become increasingly popular in the rehabilitation of patients with cleft lip and palate. A histologic basis of the performance of bone grafts is required to evaluate properly different grafting materials. This, however, cannot be provided by clinical studies on humans. Therefore, an animal model with a simulated alveolar cleft is needed. A number of animal models has been previously proposed by other investigators. The problems associated with each model are presented and a surgical technique for the creation of permanent alveolar clefts in rabbits is described. Clinical and histologic findings 6 weeks postoperatively confirm the establishment of a 1-cm wide defect with oronasal communication and healthy epithelial lining. This animal model can be efficiently used for the testing of various bone grafting materials.
牙槽骨植骨术是一种辅助性手术，在唇腭裂患者的康复治疗中越来越受欢迎。为了正确评估不同的植骨材料，需要了解骨移植性能的组织学基础。然而，人体临床研究无法提供这方面的信息。因此，需要一个模拟牙槽裂的动物模型。此前其他研究人员已经提出了多种动物模型。本文介绍了每种模型存在的问题，并描述了一种在兔子身上制造永久性牙槽裂的手术技术。术后6周的临床和组织学检查结果证实，已形成一个1厘米宽的、与口鼻相通且上皮衬里健康的缺损。这种动物模型可有效地用于测试各种骨移植材料。
