Tzischinsky O, Shlitner A, Lavie P
Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
J Biol Rhythms. 1993 Fall;8(3):199-209. doi: 10.1177/074873049300800303.
The present study investigated the relationship between the time of nocturnal onset of urinary 6-sulfatoxymelatonin (aMT6s) secretion, and the timing of the steepest increase in nocturnal sleepiness ("sleep gate"), as determined by an ultrashort sleep-wake cycle test (7 min sleep, 13 min wake). Twenty-nine men (mean age 23.8 +/- 2.7 years) participated. The ultrashort sleep-wake paradigm started at 0700 hr after a night of sleep deprivation and continued for 24 hr until 0700 hr the next day. Electrophysiological recordings were carried out during the 7-min sleep trials, which were then scored conventionally for sleep stages. Urinary aMT6s was measured every 2 hr. The results showed that the timing of the sleep gate was significantly correlated with the onset of aMT6s secretion. These results are discussed in light of the possible role of melatonin in sleep-wake regulation.
本研究调查了夜间尿中6-硫酸氧褪黑素（aMT6s）分泌开始时间与夜间嗜睡程度急剧增加的时间（“睡眠门控”）之间的关系，“睡眠门控”由超短睡眠-清醒周期测试（7分钟睡眠，13分钟清醒）确定。29名男性（平均年龄23.8±2.7岁）参与了研究。超短睡眠-清醒模式在一夜睡眠剥夺后的07:00开始，持续24小时至次日07:00。在7分钟的睡眠试验期间进行电生理记录，然后按照常规对睡眠阶段进行评分。每2小时测量一次尿aMT6s。结果表明，睡眠门控时间与aMT6s分泌开始时间显著相关。根据褪黑素在睡眠-觉醒调节中可能的作用对这些结果进行了讨论。
