Palosuo T, Andres G A, Milgrom F
Int Arch Allergy Appl Immunol. 1976;52(1-4):129-35. doi: 10.1159/000231674.
Sera and 5% PEG-precipitates from 20 patients with IMN, 18 with MPGN, 20 with SLE, 8 with anti-GBM disease and 17 with other varieties of glomerulonephritides, 19 patients with chronic liver or intestinal diseases, as well as those from 40 healthy adults, were tested by gel prcipitation for the presence of a ubiquitous tissue antigen (UTA) and/or its corresponding antibody, previously shown to be associated with renal disorders. The antigen was detected in sera of 5 patients with IMN, one with anit-GBM disease and one with SLE. Corresponding antibodies were present in sera of 2 patients with IMN. In 4 of 5 patients with IMN and UTA was only detected if the sera were first treated with PEG (mol. wt. 6,000) which induces precipitation of antigen-antibody complexes and other high molecular weight components in serum. The UTA was not detected in renal glomeruli by immunofluorescence. The possible significance of these findings in the pathogenesis of renal diseases is discussed.
对20例膜性肾病（IMN）患者、18例膜增生性肾小球肾炎（MPGN）患者、20例系统性红斑狼疮（SLE）患者、8例抗肾小球基底膜（GBM）病患者、17例其他类型肾小球肾炎患者、19例慢性肝病或肠道疾病患者以及40名健康成年人的血清和5%聚乙二醇（PEG）沉淀物进行凝胶沉淀试验，以检测一种普遍存在的组织抗原（UTA）和/或其相应抗体，此前已证明该抗原与肾脏疾病有关。在5例IMN患者、1例抗GBM病患者和1例SLE患者的血清中检测到了该抗原。2例IMN患者的血清中存在相应抗体。在5例IMN患者中有4例，只有在血清先用PEG（分子量6000）处理后才能检测到UTA，PEG可诱导血清中抗原-抗体复合物和其他高分子量成分沉淀。通过免疫荧光法在肾小球中未检测到UTA。讨论了这些发现对肾脏疾病发病机制的可能意义。
