酒精性肝病中循环免疫复合物的检测
Detection of circulating immune complexes in alcoholic liver disease.
作者信息
Penner E, Albini B, Milgrom F
出版信息
Clin Exp Immunol. 1978 Oct;34(1):28-31.
Abstract
Sera of twenty-five patients with alcoholic liver disease and forty normal control sera were screened for circulating immune complexes by means of the anti-antibody neutralization test and by Raji-cell membrane immunofluorescence assay. IgG-containing immune complexes were detected in thirteen out of twenty-five patients with alcoholic liver diseases and in one out of forty normal individuals; in addition, IgA-containing complexes were demonstrated in seven out of thirteen sera positive for IgG complexes. The presence of immune complexes was restricted to alcoholic hepatitis and active cirrhosis, thus indicating a relationship with disease severity.
摘要
采用抗抗体中和试验和拉吉细胞膜免疫荧光测定法，对25例酒精性肝病患者的血清和40份正常对照血清进行循环免疫复合物筛查。在25例酒精性肝病患者中，有13例检测到含IgG的免疫复合物，在40例正常个体中有1例检测到；此外，在13份IgG复合物阳性血清中的7份中检测到含IgA的复合物。免疫复合物的存在仅限于酒精性肝炎和活动性肝硬化，因此表明与疾病严重程度有关。
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