Morris T W
Department of Radiology, University of Rochester, New York.
Invest Radiol. 1993 Nov;28 Suppl 5:S44-6; discussion S47. doi: 10.1097/00004424-199311001-00013.
This article briefly reviews the potential physiologic effects of ionic versus nonionic contrast media on the myocardium.
Selection criteria for articles included the use of quantitative measurement techniques, controlled contrast-media doses, and a focus on cardiac mechanical or electrical function. Two important reviews also were used. Most of the data considered represent the results of animal experiments.
RESULTS/CONCLUSIONS: Nonionic monomer contrast media are associated with markedly less physiologic effect on the heart, compared with ionic agents. For instance, cardiac depression is minimal, and the incidence of arrhythmia and fibrillation is reduced with nonionic agents during coronary arteriography. Nonionic dimer agents with electrolyte supplementation produce even less mechanical and electrical disturbances.
本文简要回顾离子型与非离子型造影剂对心肌的潜在生理效应。
文章的选择标准包括使用定量测量技术、控制造影剂剂量以及关注心脏机械功能或电功能。还使用了两篇重要综述。所考虑的大多数数据代表动物实验结果。
结果/结论：与离子型造影剂相比，非离子型单聚体造影剂对心脏的生理效应明显更小。例如，心脏抑制作用最小，在冠状动脉造影期间使用非离子型造影剂时心律失常和颤动的发生率降低。补充电解质的非离子型二聚体造影剂产生的机械和电干扰甚至更小。
