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本文引用的文献

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Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo.1型人类免疫缺陷病毒母婴传播毒株env基因V1和V2区域在体内的独立变异和正向选择
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Relation of phenotype evolution of HIV-1 to envelope V2 configuration.HIV-1的表型进化与包膜V2构型的关系。
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3
Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.人类免疫缺陷病毒1型gp120糖蛋白V1/V2区域氨基酸变化对亚基缔合、合胞体形成及中和抗体识别的影响。
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HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.在疾病的临床潜伏期，HIV感染在淋巴组织中活跃且呈进行性发展。
Nature. 1993 Mar 25;362(6418):355-8. doi: 10.1038/362355a0.
5
Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers.感染儿童的1型人类免疫缺陷病毒可变区3序列与其母亲病毒群体的RNA和DNA序列的比较。
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HIV-1 proviral genotypes from the peripheral blood mononuclear cells of an infected patient are differentially represented in expressed sequences.来自一名感染患者外周血单核细胞的HIV-1前病毒基因型在表达序列中的呈现存在差异。
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7
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.通过竞争性聚合酶链反应确定，在感染的所有阶段血浆中均存在高水平的HIV-1。
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8
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS.在艾滋病潜伏期，人类免疫缺陷病毒对辅助性T淋巴细胞和巨噬细胞进行大量隐匿性感染。
Nature. 1993 Mar 25;362(6418):359-62. doi: 10.1038/362359a0.
9
Identification by HLA typing of intrauterine-derived maternal T cells in four patients with severe combined immunodeficiency.通过HLA分型鉴定四名重症联合免疫缺陷患者中源自宫内的母体T细胞。
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10
Maternal transmission of acquired immune deficiency syndrome.获得性免疫缺陷综合征的母婴传播
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通过垂直传播感染的婴儿中多种I型人类免疫缺陷病毒母体基因型的持续存在。

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

作者信息

Lamers S L, Sleasman J W, She J X, Barrie K A, Pomeroy S M, Barrett D J, Goodenow M M

机构信息

Department of Pathology, University of Florida College of Medicine, Gainesville 32610.

出版信息

J Clin Invest. 1994 Jan;93(1):380-90. doi: 10.1172/JCI116970.

DOI:10.1172/JCI116970
PMID:8282808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293789/
Abstract

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.

摘要

HIV-1包膜高变区内核苷酸变异的程度，可作为感染个体内病毒基因型的一个标志物，以及追踪个体间病毒传播的一种手段。我们分析了来自两名感染HIV-1的母亲的纵向样本中的env V1和V2序列，每名母亲有三名通过母婴传播感染病毒的孩子。出生后2天和4周从两名婴儿处获得的样本中的序列，在V1和V2中显示出比同一时间获得的母亲样本更多的变异。在每名母亲中鉴定出多种HIV-1基因型。在每个家庭中，多种母亲HIV-1基因型传播给了婴儿。高变区内的特定氨基酸残基在每个家庭的序列中是保守的，在V1和V2中产生了一种家庭特异性的氨基酸特征模式。在特征模式上与母亲病毒高度相关的病毒，在年龄较大的儿童中持续存在长达4年。结果支持一种传播模型，该模型涉及多种HIV-1基因型，且随着每个个体内基因变化的差异生长和积累而发生遗传变异。