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1985年至1990年3个月以下婴儿主动脉缩窄的外科治疗:扩大端端主动脉弓成形术的成功经验

Surgical treatment of aortic coarctation in infants younger than three months: 1985 to 1990. Success of extended end-to-end arch aortoplasty.

作者信息

van Heurn L W, Wong C M, Spiegelhalter D J, Sorensen K, de Leval M R, Stark J, Elliott M J

机构信息

Medical Research Council, Biostatistics Unit, Cambridge, England.

出版信息

J Thorac Cardiovasc Surg. 1994 Jan;107(1):74-85; discussion 85-6.

PMID:8283922
Abstract

There remains controversy regarding the appropriate surgical treatment of coarctation of the aorta in infants. In 1985 we introduced the extended end-to-end repair into our practice and now wish to present a review of our recent experience. One hundred fifty-one infants younger than 3 months of age underwent repair of coarctation between 1985 and 1990. In 25% and 33% of the patients, there was hypoplasia of the isthmus and of the transverse arch, respectively. Surgical procedures were as follows: subclavian flap angioplasty in 15 patients, resection with a traditional end-to-end anastomosis in 43, and resection with an extended end-to-end anastomosis into the arch in 77. In 30 patients, the extension was proximal to the origin of the left carotid artery (radically extended end-to-end anastomosis). Other procedures were used in 16 patients. Mortality (13 early and 12 late deaths) was related on multivariate analysis to the presence of an associated major heart defect, preoperative resuscitation, and direct postoperative gradient over the arch. This immediate postoperative gradient was significantly lower after both extended and radically extended end-to-end anastomosis if there was a hypoplastic isthmus, and after radically extended end-to-end anastomosis if the transverse arch was hypoplastic. Actuarial freedom from recoarctation at 4 years was 57% (confidence limits 28% to 78%) after subclavian flap angioplasty, 77% (confidence limits 60% to 87%) after end-to-end anastomosis, 83% (confidence limits 66% to 92%) after extended end-to-end anastomosis and 96% (confidence limits 77% to 100%) after radically extended end-to-end anastomosis. We conclude that the extended end-to-end anastomosis and radical end-to-end anastomosis appear to offer the best prognosis for all infants with coarctation. The technique can be applied successfully to almost all types of arch anomalies.

摘要

关于婴儿主动脉缩窄的合适手术治疗方法仍存在争议。1985年我们在临床实践中引入了扩大端端修复术,现希望汇报我们近期的经验。1985年至1990年间,151例3个月以下婴儿接受了主动脉缩窄修复术。分别有25%和33%的患者存在峡部及横弓发育不全。手术方式如下:15例患者行锁骨下瓣血管成形术,43例行传统端端吻合切除术,77例行扩大端端吻合至主动脉弓切除术。30例患者的吻合延伸至左颈动脉起始部近端(根治性扩大端端吻合)。16例患者采用了其他手术方式。多因素分析显示,死亡率(13例早期死亡和12例晚期死亡)与合并主要心脏缺陷、术前复苏及术后主动脉弓直接压差有关。若峡部发育不全,扩大端端吻合及根治性扩大端端吻合术后的即刻术后压差显著更低;若横弓发育不全,则根治性扩大端端吻合术后的压差显著更低。锁骨下瓣血管成形术后4年无再缩窄的精算生存率为57%(可信区间28%至78%),端端吻合术后为77%(可信区间60%至87%),扩大端端吻合术后为83%(可信区间66%至92%),根治性扩大端端吻合术后为96%(可信区间77%至100%)。我们得出结论,扩大端端吻合术和根治性端端吻合术似乎为所有主动脉缩窄婴儿提供了最佳预后。该技术可成功应用于几乎所有类型的主动脉弓畸形。

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