Heinic G S, Stevens D A, Greenspan D, MacPhail L A, Dodd C L, Stringari S, Strull W M, Hollander H
Department of Stomatology, University of California, San Francisco.
Oral Surg Oral Med Oral Pathol. 1993 Dec;76(6):711-5. doi: 10.1016/0030-4220(93)90039-7.
Oropharyngeal candidiasis develops in up to 95% of patients with acquired immunodeficiency syndrome. Oral fluconazole is frequently prescribed for persons who are human immunodeficiency virus-seropositive as initial or suppressive therapy for oropharyngeal and esophageal candidiasis or as suppressive therapy for cryptococcal meningitis. We report two cases of oropharyngeal candidiasis, caused by Candida albicans, which developed in two patients with acquired immunodeficiency syndrome who had taken fluconazole for extended periods. In addition to the clinical resistance we observed, isolates of the organism appeared to be resistant in vitro to fluconazole and ketoconazole.
高达95%的获得性免疫缺陷综合征患者会发生口咽念珠菌病。口服氟康唑经常被开给人类免疫缺陷病毒血清反应阳性的人，作为口咽和食管念珠菌病的初始或抑制疗法，或作为隐球菌性脑膜炎的抑制疗法。我们报告了两例由白色念珠菌引起的口咽念珠菌病病例，这两名获得性免疫缺陷综合征患者长期服用氟康唑。除了我们观察到的临床耐药性外，该生物体的分离株在体外似乎对氟康唑和酮康唑也耐药。
