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Oropharyngeal candidiasis resistant to single-dose therapy with fluconazole in HIV-infected patients.

作者信息

Vuffray A, Durussel C, Boerlin P, Boerlin-Petzold F, Bille J, Glauser M P, Chave J P

出版信息

AIDS. 1994 May;8(5):708-9. doi: 10.1097/00002030-199405000-00023.

DOI:10.1097/00002030-199405000-00023
PMID:8060555
Abstract
摘要

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Oropharyngeal candidiasis resistant to single-dose therapy with fluconazole in HIV-infected patients.在HIV感染患者中对氟康唑单剂量治疗耐药的口咽念珠菌病
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Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents.来自唑类耐药白色念珠菌临床分离株的细胞色素P-450羊毛甾醇14α-脱甲基酶（CYP51A1）中的氨基酸取代导致对唑类抗真菌药物产生耐药性。
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