Hatada I, Sugama T, Mukai T
National Cardiovascular Center Research Institute, Osaka, Japan.
Nucleic Acids Res. 1993 Dec 11;21(24):5577-82. doi: 10.1093/nar/21.24.5577.
We cloned a new imprinted gene by searching for parental-origin-specific CpG methylations using methylation-sensitive two-dimensional genome scanning method. This gene encodes a putative 51 kDa protein with significant similarity to U2 small nuclear ribonucleoprotein auxiliary factor small subunits, an essential mammalian splicing factor, and is located on mouse chromosome 11, of which maternal duplication/paternal deficiency results in a small body.
我们通过使用甲基化敏感二维基因组扫描方法寻找亲本来源特异性的CpG甲基化，克隆了一个新的印记基因。该基因编码一种推定的51 kDa蛋白质，与U2小核核糖核蛋白辅助因子小亚基（一种必需的哺乳动物剪接因子）具有显著相似性，位于小鼠11号染色体上，其母本重复/父本缺失会导致体型变小。
