Takashima A, Maeda Y, Itoh S
Shionogi Research Laboratories (Aburahi Branch), Osaka, Japan.
Peptides. 1993 Sep-Oct;14(5):1073-8. doi: 10.1016/0196-9781(93)90089-y.
In our previous study, bolus injection of VIP into the lateral cerebral ventricle, at nonphysiological high doses, has been shown to produce amnesia. Accordingly, in the present study, VIP was infused chronically into the cerebral ventricle of the rat at a rate of 10 ng per day for 2 weeks. During the infusion period, the animals were subjected to the Morris water pool test. The VIP infusion caused an apparent impairment of memory, particularly in the acquisition of new information; VIP(1-12) also caused similar impairment, but to a lesser extent. The VIP antagonists did not affect the performance of learned tasks. However, cerulein treatment prevented the VIP-induced memory impairment.
在我们之前的研究中，已表明以非生理高剂量向大鼠侧脑室一次性注射血管活性肠肽（VIP）会导致失忆。因此，在本研究中，以每天10纳克的速率将VIP长期注入大鼠脑室，持续2周。在注入期间，对动物进行莫里斯水迷宫试验。注入VIP导致明显的记忆损害，尤其是在获取新信息方面；VIP（1-12）也导致类似损害，但程度较轻。VIP拮抗剂不影响已学任务的表现。然而，蛙皮素治疗可预防VIP诱导的记忆损害。
