Vorob'ev K V, Rudenko L G, Islamova I T, Grigor'eva E P, Egorov A Iu, Ermachenko T A, Chepik E B, Zakharova N G, Karachentsev A M
Vopr Virusol. 1991 Nov-Dec;36(6):475-7.
The capacity of a live influenza vaccine (LIV) to stimulate cytotoxic cells (ADCMC and NK) was studied in 49 volunteers and 56 patients with influenza. Experimental batches of LIV from influenza A and B viruses prepared by genetic recombination on the basis of cold-adapted attenuation donors were used. Type A and B LIV were shown to stimulate the cytotoxic cell-mediated and humoral immunity; the intensity of immune response, however, depended on the molecular genetic characteristics of the vaccine (genome structure, properties of the donor of attenuation), its biological activity and capacity of reproduction in tissues.
在49名志愿者和56名流感患者中研究了流感活疫苗（LIV）刺激细胞毒性细胞（ADCMC和NK）的能力。使用了基于冷适应减毒供体通过基因重组制备的甲型和乙型流感病毒的实验批次LIV。甲型和乙型LIV均显示出能刺激细胞毒性细胞介导的免疫和体液免疫；然而，免疫反应的强度取决于疫苗的分子遗传特征（基因组结构、减毒供体的特性）、其生物活性以及在组织中的繁殖能力。
