[Two novel bisbenzylisoquinoline alkaloids from Cyclea sutchuenensis Gagnep].

In addition to the known cycleanine (I) and d-isochondodendrine (II), two novel bisbenzylisoquinoline alkaloids named isocycleanine (III) and sutchuenensine (IV) have been isolated from the roots of Cyclea sutchuenensis Gagnep grown wild in Sichuan province, China. III was established as the epimer of I and IV, as a new type of head-to-tail bisbenzylisoquinoline alkaloid with two diarylether bridges in between C-8 to C-12' and C-12 to C-7' on the basis of physical constants and spectral data (UV, IR, EIMS, 1HNMR and NOEDS).