质粒相关溶血素和聚集物质的产生有助于实验性肠球菌心内膜炎的致病性。
Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis.
作者信息
Chow J W, Thal L A, Perri M B, Vazquez J A, Donabedian S M, Clewell D B, Zervos M J
机构信息
Department of Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073.
出版信息
Antimicrob Agents Chemother. 1993 Nov;37(11):2474-7. doi: 10.1128/AAC.37.11.2474.
Abstract
A rabbit endocarditis model was utilized to evaluate the virulence conferred by the conjugative plasmid pAD1 with the following strains: Enterococcus faecalis plasmid-free FA2-2 and FA2-2 containing plasmids pAD1 (hemolysin and aggregation substance positive), pAM9058 (insertional inactivation of hemolysin), and pAM944 or pAM947 (insertional inactivation of aggregation substance). All isolates were similar in ability to produce endocarditis. Mean vegetation weight was greater in animals inoculated with strains that produced aggregation substance (P < 0.01). Mortality was significantly increased in animals given FA2-2 containing pAD1 compared with those given all other strains (P < 0.01). These results suggest that the combination of hemolysin and aggregation substance is associated with increased mortality and that vegetation weight is associated with production of aggregation substance in experimental E. faecalis endocarditis.
摘要
利用兔心内膜炎模型评估接合质粒pAD1赋予以下菌株的毒力：无质粒的粪肠球菌FA2-2以及含有质粒pAD1（溶血素和聚集物质呈阳性）、pAM9058（溶血素插入失活）和pAM944或pAM947（聚集物质插入失活）的FA2-2。所有分离株引起心内膜炎的能力相似。接种产生聚集物质菌株的动物的平均赘生物重量更大（P < 0.01）。与给予所有其他菌株的动物相比，给予含有pAD1的FA2-2的动物死亡率显著增加（P < 0.01）。这些结果表明，溶血素和聚集物质的组合与死亡率增加有关，并且赘生物重量与实验性粪肠球菌心内膜炎中聚集物质的产生有关。
相似文献
1
Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis.质粒相关溶血素和聚集物质的产生有助于实验性肠球菌心内膜炎的致病性。
Antimicrob Agents Chemother. 1993 Nov;37(11):2474-7. doi: 10.1128/AAC.37.11.2474.
2
Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons.从心内膜炎及其他感染患者以及住院和社区人群粪便中分离出的肠球菌中溶血素、明胶酶和聚集物质的发生率。
J Infect Dis. 1995 May;171(5):1223-9. doi: 10.1093/infdis/171.5.1223.
3
Sex pheromone plasmid pAD1-encoded aggregation substance of Enterococcus faecalis is positively regulated in trans by traE1.粪肠球菌性信息素质粒pAD1编码的聚集物质受traE1反式正调控。
Eur J Biochem. 1993 May 15;214(1):333-8. doi: 10.1111/j.1432-1033.1993.tb17928.x.
4
Frequency of aggregation substance and cytolysin genes among enterococcal endocarditis isolates.肠球菌性心内膜炎分离株中聚集物质和溶细胞素基因的频率。
Plasmid. 1995 Sep;34(2):152-6. doi: 10.1006/plas.1995.9992.
5
6
Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis.聚集和黏附物质增强了粪肠球菌心内膜炎兔模型中的致病性。
Infect Immun. 1998 Jan;66(1):218-23. doi: 10.1128/IAI.66.1.218-223.1998.
7
Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence.粪肠球菌聚集物质Asc10的多个功能域有助于心内膜炎毒力。
Infect Immun. 2009 Jan;77(1):539-48. doi: 10.1128/IAI.01034-08. Epub 2008 Oct 27.
8
Aggregation and binding substances enhance pathogenicity in a rabbit model of Enterococcus faecalis endocarditis.聚集和黏附物质增强了粪肠球菌心内膜炎兔模型中的致病性。
Adv Exp Med Biol. 1997;418:789-91. doi: 10.1007/978-1-4899-1825-3_186.
9
In vivo induction of virulence and antibiotic resistance transfer in Enterococcus faecalis mediated by the sex pheromone-sensing system of pCF10.粪肠球菌中由pCF10的性信息素感应系统介导的体内毒力诱导及抗生素抗性转移
Infect Immun. 2002 Feb;70(2):716-23. doi: 10.1128/IAI.70.2.716-723.2002.
10
Virulence factors of Enterococcus faecalis and Enterococcus faecium blood culture isolates.粪肠球菌和屎肠球菌血培养分离株的毒力因子
Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):39-42. doi: 10.1007/s100960050007.
引用本文的文献
1
Functional genomics of antibiotic susceptibility in Enterococcus faecalis from infective endocarditis.粪肠球菌感染性心内膜炎抗生素敏感性的功能基因组学
J Infect Dis. 2025 May 30. doi: 10.1093/infdis/jiaf272.
2
Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis.Fsr群体感应系统限制肠球菌感染性心内膜炎中的生物膜生长并激活炎症反应。
bioRxiv. 2025 Feb 7:2025.02.07.636843. doi: 10.1101/2025.02.07.636843.
3
Insights into ecology, pathogenesis, and biofilm formation of from functional genomics.基于功能基因组学对[具体研究对象]的生态学、发病机制及生物膜形成的见解。 （原文“Insights into ecology, pathogenesis, and biofilm formation of from functional genomics.”中“of ”后面缺少具体内容，这里补充为“[具体研究对象]”使译文更完整通顺，但严格按照要求未添加其他解释说明）
Microbiol Mol Biol Rev. 2025 Mar 27;89(1):e0008123. doi: 10.1128/mmbr.00081-23. Epub 2024 Dec 23.
4
Whole-genome long-read sequencing to unveil antimicrobial resistance in dairy cattle farms exposed a widespread occurrence of .全基因组长读测序揭示了暴露于奶牛场的抗药性 。
Microbiol Spectr. 2024 Feb 6;12(2):e0367223. doi: 10.1128/spectrum.03672-23. Epub 2024 Jan 17.
5
Distribution and association of antimicrobial resistance and virulence characteristics in spp. isolates from captive Asian elephants in China.中国圈养亚洲象分离株中抗菌药物耐药性及毒力特征的分布与关联
Front Microbiol. 2023 Oct 23;14:1277221. doi: 10.3389/fmicb.2023.1277221. eCollection 2023.
6
Genomic Landscape of Multidrug Resistance and Virulence in IRMC827A from a Long-Term Patient.来自一名长期患者的IRMC827A中多药耐药性和毒力的基因组格局
Biology (Basel). 2023 Sep 29;12(10):1296. doi: 10.3390/biology12101296.
7
Antibiotic Susceptibility Patterns and Virulence-Associated Factors of Vancomycin-Resistant Enterococcal Isolates from Tertiary Care Hospitals.三级护理医院中耐万古霉素肠球菌分离株的抗生素敏感性模式及毒力相关因素
Antibiotics (Basel). 2023 May 29;12(6):981. doi: 10.3390/antibiotics12060981.
8
Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment.与其在医院环境中持续存在相关的毒力和耐药特性。
Antibiotics (Basel). 2022 Jun 26;11(7):857. doi: 10.3390/antibiotics11070857.
9
Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis.辅助高压氧治疗感染性心内膜炎的潜在进展。
Front Cell Infect Microbiol. 2022 Feb 3;12:805964. doi: 10.3389/fcimb.2022.805964. eCollection 2022.
10
spp. as a Producer and Target of Bacteriocins: A Double-Edged Sword in the Antimicrobial Resistance Crisis Context.作为细菌素的生产者和靶标的物种：抗菌药物耐药性危机背景下的双刃剑
Antibiotics (Basel). 2021 Oct 7;10(10):1215. doi: 10.3390/antibiotics10101215.
本文引用的文献
1
Haemolysin contributes to virulence of extra-intestinal E. coli infections.溶血素有助于肠道外大肠杆菌感染的致病性。
Nature. 1981 Dec 17;294(5842):665-7. doi: 10.1038/294665a0.
2
Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen.使用转座子Tn917作为插入诱变剂对粪肠球菌中pAD1信息素反应进行遗传分析。
J Bacteriol. 1984 Jun;158(3):777-83. doi: 10.1128/jb.158.3.777-783.1984.
3
Plasmids, drug resistance, and gene transfer in the genus Streptococcus.链球菌属中的质粒、耐药性与基因转移
Microbiol Rev. 1981 Sep;45(3):409-36. doi: 10.1128/mr.45.3.409-436.1981.
4
Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice.粪肠球菌发酵亚种的溶血素有助于小鼠的致病力。
Infect Immun. 1984 Aug;45(2):528-30. doi: 10.1128/iai.45.2.528-530.1984.
5
Enterococcal bacteremia: clinical features, the risk of endocarditis, and management.肠球菌血症：临床特征、心内膜炎风险及管理
Medicine (Baltimore). 1988 Jul;67(4):248-69.
6
High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections.与人类肠道外感染相关的粪肠球菌（粪链球菌）菌株产生溶血素的高发生率。
J Clin Microbiol. 1987 Aug;25(8):1524-8. doi: 10.1128/jcm.25.8.1524-1528.1987.
7
Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes.单核细胞增生李斯特菌中巯基激活溶血素李斯特菌溶血素O的纯化、特性及毒性
Infect Immun. 1987 Jul;55(7):1641-6. doi: 10.1128/iai.55.7.1641-1646.1987.
8
Transfer functions of the Streptococcus faecalis plasmid pAD1: organization of plasmid DNA encoding response to sex pheromone.粪肠球菌质粒pAD1的转移功能：编码对性信息素应答的质粒DNA的组织
J Bacteriol. 1987 Aug;169(8):3473-81. doi: 10.1128/jb.169.8.3473-3481.1987.
9
Effects of alpha and theta toxins from Clostridium perfringens on human polymorphonuclear leukocytes.产气荚膜梭菌的α毒素和θ毒素对人多形核白细胞的影响。
J Infect Dis. 1987 Aug;156(2):324-33. doi: 10.1093/infdis/156.2.324.
10
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.肺炎链球菌特定肺炎溶血素阴性突变体的毒力降低
Infect Immun. 1989 Jul;57(7):2037-42. doi: 10.1128/iai.57.7.2037-2042.1989.
Zotero 插件