Coque T M, Patterson J E, Steckelberg J M, Murray B E
Department of Internal Medicine, University of Texas Medical School, Houston 77030, USA.
J Infect Dis. 1995 May;171(5):1223-9. doi: 10.1093/infdis/171.5.1223.
The presence of hemolysin, gelatinase, and aggregation substance (by use of a probe known to hybridize to most pheromone-responsive plasmids) was determined in 192 isolates of Enterococcus faecalis from patients with endocarditis or other infections and fecal isolates from hospitalized patients or healthy volunteers, and in 86 non-E. faecalis isolates. Hemolysin was more common in nonendocarditis clinical isolates and in hospital fecal isolates (37% and 31%, respectively) than among endocarditis and community fecal isolates (16% and 20%, respectively). Gelatinase and aggregation substance, respectively, were found in 54% and 52% of isolates from endocarditis, in 58% and 72% of isolates from other infections, in 62% and 56% of hospital fecal isolates, and in 27% and 30% of fecal isolates from healthy volunteers. All 86 non-E. faecalis enterococcal isolates were negative for these traits. The absence of hemolysin, gelatinase, or the aggregation substance gene in > 45% of endocarditis E. faecalis isolates suggests that while these traits may play a role in virulence, other properties are also important.
在192株来自心内膜炎或其他感染患者的粪肠球菌分离株、住院患者或健康志愿者的粪便分离株以及86株非粪肠球菌分离株中，检测了溶血素、明胶酶和聚集物质（使用已知能与大多数信息素反应性质粒杂交的探针）。溶血素在非心内膜炎临床分离株和医院粪便分离株中更为常见（分别为37%和31%），而在心内膜炎和社区粪便分离株中较少见（分别为16%和20%）。明胶酶和聚集物质分别在54%的心内膜炎分离株、58%的其他感染分离株、62%的医院粪便分离株以及27%的健康志愿者粪便分离株中被发现，在72%的医院粪便分离株以及30%的健康志愿者粪便分离株中被发现。所有86株非粪肠球菌肠球菌分离株的这些特征均为阴性。超过45%的心内膜炎粪肠球菌分离株中不存在溶血素、明胶酶或聚集物质基因，这表明虽然这些特征可能在毒力中起作用，但其他特性也很重要。
