在万古霉素存在的情况下，铜绿假单胞菌对环丙沙星的敏感性增加。
Increased susceptibility of Pseudomonas aeruginosa to ciprofloxacin in the presence of vancomycin.
作者信息
Day C A, Marceau-Day M L, Day D F
机构信息
St. Joseph's Academy, Baton Rouge, Louisiana.
出版信息
Antimicrob Agents Chemother. 1993 Nov;37(11):2506-8. doi: 10.1128/AAC.37.11.2506.
Abstract
Vancomycin in combination with ciprofloxacin exhibited synergy against 7 of 10 strains of Pseudomonas aeruginosa. MICs for the microbial strains used in this study ranged from 0.0325 to 3.0 micrograms/ml for ciprofloxacin and from 23.5 to > 188 micrograms/ml for vancomycin. Combinations of these antibiotics, tested in a checkerboard pattern, gave fractional inhibitory concentrations of 0.5 or less for 7 of the 10 strains tested.
摘要
万古霉素与环丙沙星联合使用对10株铜绿假单胞菌中的7株表现出协同作用。本研究中所用微生物菌株的环丙沙星最低抑菌浓度（MIC）范围为0.0325至3.0微克/毫升，万古霉素的MIC范围为23.5至>188微克/毫升。以棋盘格模式测试这些抗生素的组合，在所测试的10株菌株中有7株的部分抑菌浓度为0.5或更低。
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