Waterfield C J, Turton J A, Scales M D, Timbrell J A
Department of Toxicology, School of Pharmacy, London, UK.
Arch Toxicol. 1993;67(8):538-46. doi: 10.1007/BF01969266.
Administration of compounds which alter protein synthesis or sulphur amino acid metabolism in rats results in changes in the excretion of urinary taurine. Treatment with diethylmaleate (DEM) or phorone, which will deplete glutathione (GSH), reduces taurine excretion, whereas treatment with buthionine sulphoximine (BSO), which will inhibit glutathione synthesis, increases taurine excretion. Treatment with cycloheximide, an inhibitor of protein synthesis, increases taurine excretion, whereas pretreatment with phenobarbital, which will increase protein synthesis, decreases taurine excretion. Administration of agents which damage organs other than the liver such as the kidney, heart and testes, does not increase urinary taurine.
给大鼠施用改变蛋白质合成或硫氨基酸代谢的化合物会导致尿中牛磺酸排泄量的变化。用马来酸二乙酯（DEM）或佛尔酮处理会消耗谷胱甘肽（GSH），从而降低牛磺酸排泄量，而用丁硫氨酸亚砜胺（BSO）处理会抑制谷胱甘肽合成，从而增加牛磺酸排泄量。用蛋白质合成抑制剂环己酰亚胺处理会增加牛磺酸排泄量，而用苯巴比妥预处理会增加蛋白质合成，从而降低牛磺酸排泄量。施用损害肝脏以外器官（如肾脏、心脏和睾丸）的药物不会增加尿中牛磺酸含量。
