Waterfield C J, Asker D S, Patel S, Timbrell J A
Toxicology Department, School of Pharmacy, London, United Kingdom.
Amino Acids. 1998;15(1-2):161-77. doi: 10.1007/BF01345289.
Changes in urinary levels of taurine have been reported in rats following treatment with various xenobiotics including those which alter protein synthesis and/or are hepatotoxic. This paper reports on the time course of the urinary elevation of taurine following treatment of rats with tetracycline (50, 150 and 200 mg.kg-1). Maximum taurine excretion occurred 8-12 h following dosing. Serum albumin and total protein were significantly lower after 24 h (200 mg.kg-1). The increase in urinary taurine was dose-related and reflected in the raised serum levels of taurine 24 h after dosing. Serum and urinary protein and [3H]-leucine incorporation into acid precipitable protein in liver and muscle were reduced by tetracycline (100, 150 and 200 mg.kg-1) 10 h after dosing. The reduction in protein synthesis was correlated with increased urinary and serum levels of taurine at 10 h. The use of taurine as a non-invasive marker of protein synthesis is discussed.
据报道，用包括那些改变蛋白质合成和/或具有肝毒性的各种异生物质处理大鼠后，其尿中牛磺酸水平会发生变化。本文报道了用四环素（50、150和200mg·kg-1）处理大鼠后尿中牛磺酸升高的时间进程。给药后8-12小时牛磺酸排泄量达到最大。24小时后（200mg·kg-1）血清白蛋白和总蛋白显著降低。尿中牛磺酸的增加与剂量相关，并在给药后24小时血清牛磺酸水平升高上得到体现。给药10小时后，四环素（100、150和200mg·kg-1）使血清和尿蛋白以及肝脏和肌肉中酸沉淀蛋白中[3H]-亮氨酸的掺入减少。蛋白质合成的减少与10小时时尿和血清中牛磺酸水平的升高相关。文中讨论了将牛磺酸用作蛋白质合成的非侵入性标志物的用途。
