Hilleman M R, Buynak E B, Roehm R R, Tytell A A, Bertland A U, Lampson G P
Am J Med Sci. 1975 Sep-Oct;270(2):401-4. doi: 10.1097/00000441-197509000-00025.
Developments leading to the preparation and testing for safety and potency of a highly purified inactivated preparation of hepatitis B surface antigen are descirbed. Protective efficacy studies in chimps of a lot of the inactivated hepatitis B vaccine are currently and suitable for clinical trials in man.
本文描述了导致制备高纯度乙肝表面抗原灭活制剂并进行安全性和效力测试的进展情况。目前，一批灭活乙肝疫苗在黑猩猩身上的保护效力研究结果适用于人体临床试验。
