Kalinin N L, Goncharov D B, Shakhanina K L, Safjanova V M
Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Mol Gen Mikrobiol Virusol. 1993 Sep-Oct(5):29-31.
It was demonstrated that soybean agglutinin and peanut agglutinin aggregated all the investigated species of Leishmania, including virulent and avirulent members of L. major in agglutination tests. Concanavalin A and Pisum sativum agglutinin were shown to aggregate L. species ZMA and L. major but showed no effect on L. gymnodactyli and L. mexicana amazonensis which were aggregated by wheat germ agglutinin, an extract from Ulex europaeus and Ricinus communis. There was no correlation between the results of ELLBA studied in agglutination tests. The results indicate that the surfaces of Leishmania strains and species are heterogeneous with respect to lectin binding. There are possibly two subsets of lectin receptors on the surface structures of Leishmania cells.
在凝集试验中已证明，大豆凝集素和花生凝集素能凝集所有被研究的利什曼原虫物种，包括硕大利什曼原虫的强毒株和无毒株。已表明伴刀豆球蛋白A和豌豆凝集素能凝集ZMA利什曼原虫物种和硕大利什曼原虫，但对裸指利什曼原虫和亚马逊利什曼原虫无作用，而小麦胚凝集素、荆豆提取物和蓖麻凝集素能凝集这两种原虫。在凝集试验中研究的ELLBA结果之间没有相关性。结果表明，利什曼原虫菌株和物种的表面在凝集素结合方面是异质的。利什曼原虫细胞表面结构上可能存在两个凝集素受体亚群。
