Bücheler J, Giger U
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010.
Vet Immunol Immunopathol. 1993 Oct;38(3-4):283-95. doi: 10.1016/0165-2427(93)90088-l.
This study characterizes the naturally occurring feline alloantibodies against A and B blood type. All examined type-A and type-B cats had naturally occurring antibodies against erythrocytes of the opposite blood type. In order to determine the class of immunoglobulins, sera from cats were analyzed using incubation with 2-mercaptoethanol (2-ME), immunoprecipitation, and gel filtration. Type-A cats had weak agglutinins of the IgM class and weak hemolysins which consisted of approximately equal parts of IgG and IgM class. Type-B cats had strong hemagglutinins and hemolysins mostly of the IgM class. Colostral antibodies were detectable in newborns as early as 4 h after birth and their own alloantibody production started at 6-8 weeks of age. The presence of naturally occurring alloantibodies, in particular the anti-A alloantibodies, renders cats susceptible to clinical incompatibility reactions.
本研究对天然存在的猫抗A和B血型同种抗体进行了表征。所有检测的A型和B型猫都天然存在针对相反血型红细胞的抗体。为了确定免疫球蛋白的类别，使用2-巯基乙醇（2-ME）孵育、免疫沉淀和凝胶过滤对猫的血清进行了分析。A型猫具有IgM类的弱凝集素和由大约等量的IgG和IgM类组成的弱溶血素。B型猫具有主要为IgM类的强血凝素和溶血素。初乳抗体在新生儿出生后4小时即可检测到，它们自身的同种抗体产生始于6-8周龄。天然存在的同种抗体的存在，尤其是抗A同种抗体，使猫易发生临床不相容反应。
