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γ干扰素严重抑制巨噬细胞系中牛痘病毒的DNA合成。

Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line.

作者信息

Mĕlková Z, Esteban M

机构信息

Department of Biochemistry, State University of New York, Brooklyn 11203.

出版信息

Virology. 1994 Feb;198(2):731-5. doi: 10.1006/viro.1994.1087.

DOI:10.1006/viro.1994.1087
PMID:8291253
Abstract

Interferon-gamma inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-gamma inhibits the growth of vaccinia virus (VV) in a dose-dependent manner. This inhibition is due to a block in VV DNA synthesis and correlates with an increased generation of reactive nitrogen intermediates.

摘要

γ干扰素可抑制多种病毒的生长；然而，这种抑制的确切机制尚未明确界定。在本报告中，我们表明，在单核细胞/巨噬细胞系J774.G8中，γ干扰素以剂量依赖方式抑制痘苗病毒（VV）的生长。这种抑制是由于VV DNA合成受阻，且与活性氮中间体生成增加相关。

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