Kita R, Enokihara H, Nagashima S, Tsunogake S, Yamato H, Saito K, Furusawa S, Shishido H, Fukushima Y, Fukuda T
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Acta Haematol. 1993;90(3):144-7. doi: 10.1159/000204396.
We describe a patient with common acute lymphoblastic leukemia associated with blood and cerebrospinal fluid (CSF) eosinophilia. Serum obtained at onset and conditioned medium prepared from T cells obtained at remission stimulated with interleukin-2 contained eosinophil colony stimulating activity (Eo-CSA), which was confirmed to be predominantly GM-CSF. Leukemic cell conditioned medium and serum obtained at remission contained no Eo-CSA. The CSF contained increased eosinophil chemotactic activity, however, this factor was not identified.
我们描述了一名患有常见急性淋巴细胞白血病且伴有血液和脑脊液嗜酸性粒细胞增多的患者。发病时获取的血清以及缓解期获取的T细胞用白细胞介素-2刺激后制备的条件培养基中含有嗜酸性粒细胞集落刺激活性（Eo-CSA），经证实其主要为粒细胞-巨噬细胞集落刺激因子（GM-CSF）。缓解期获取的白血病细胞条件培养基和血清中不含Eo-CSA。脑脊液中嗜酸性粒细胞趋化活性增加，然而，该因子未被鉴定。
