Giordano P, Courdi A, Gioanni J, Bourgeon Y, Abbes M
Service de Chirurgie, Centre Antoine-Lacassagne, Nice.
Ann Chir Plast Esthet. 1993 Feb;38(1):62-8.
In order to study the influence of irradiation during skin expansion, an experimental protocol using 15 laboratory rats was undertaken. The present experiment was designed to evaluate the mitotic activity of the epidermis by in vitro autoradiography. The mitotic activity was assessed by the Labelling Index. Experimental data concerning expansion were shown to be consistent with the literature. When a high dose of radiation was delivered to the skin during expansion, a significant increase was observed in the mitotic activity of the epidermis. The range of variation was equivalent to that expected in normal skin. This is the first experimental result in favour of irradiation during skin expansion. However, no conclusion can be drawn concerning the clinical applications (immediate breast reconstruction using tissue expansion) due to the limitations of the present experiment.
为了研究皮肤扩张过程中照射的影响，采用了一项使用15只实验大鼠的实验方案。本实验旨在通过体外放射自显影评估表皮的有丝分裂活性。有丝分裂活性通过标记指数进行评估。有关扩张的实验数据与文献一致。当在扩张过程中对皮肤给予高剂量辐射时，观察到表皮有丝分裂活性显著增加。变化范围与正常皮肤预期的相当。这是支持皮肤扩张过程中进行照射的首个实验结果。然而，由于本实验的局限性，关于临床应用（使用组织扩张进行即时乳房重建）无法得出结论。
