Maes M, Scharpé S, Meltzer H Y, Cosyns P
Department of Psychiatry, University Hospitals of Cleveland, OH 44106-5000.
Biol Psychiatry. 1993 Nov 15;34(10):690-701. doi: 10.1016/0006-3223(93)90042-c.
Recently, it was found that major depression is accompanied by an acute phase (AP) response with increased haptoglobin (Hp) plasma levels and various indices of systemic immune stimulation. The present study has been carried out in order to determine the relationships between hyperhaptoglobinemia and indices of systemic immune activation in severe depression. Toward this end, the authors investigated the relationships between Hp levels and number of leukocytes, monocytes, neutrophils, lymphocytes, and activated T lymphocytes (CD25+, HLA-DR+), in depression. Hp plasma levels were significantly higher in major depressed subjects as compared to healthy controls and minor depressives. There was a significant positive correlation between Hp levels and severity of illness. Hp plasma levels showed significant and positive relationships with the absolute number of leukocytes, neutrophils, monocytes, CD25+ and HLA-DR+ T cells. Up to 35% of the variance in Hp levels could be explained by the regression on the number of neutrophils and HLA-DR+ T cells. The results show that hyperhaptoglobinemia in major depression is significantly related to activation of cell-mediated immunity.
最近发现，重度抑郁症伴有急性期（AP）反应，其特征为血浆触珠蛋白（Hp）水平升高以及全身免疫刺激的各种指标。开展本研究是为了确定重度抑郁症患者中高触珠蛋白血症与全身免疫激活指标之间的关系。为此，作者研究了抑郁症患者中Hp水平与白细胞、单核细胞、中性粒细胞、淋巴细胞及活化T淋巴细胞（CD25 +、HLA - DR +）数量之间的关系。与健康对照者和轻度抑郁症患者相比，重度抑郁症患者的血浆Hp水平显著更高。Hp水平与疾病严重程度之间存在显著正相关。血浆Hp水平与白细胞、中性粒细胞、单核细胞、CD25 +和HLA - DR + T细胞的绝对数量呈显著正相关。高达35%的Hp水平变异可由中性粒细胞和HLA - DR + T细胞数量的回归分析来解释。结果表明，重度抑郁症中的高触珠蛋白血症与细胞介导的免疫激活显著相关。
