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产前和产后暴露于饮食抗原所产生的免疫耐受。

Immune tolerance produced by pre- and postnatal exposure to dietary antigens.

作者信息

Pathirana C, Goulding N J, Gibney M J, Pitts J M, Gallagher P J, Taylor T G

出版信息

Int Arch Allergy Appl Immunol. 1981;66(1):114-8. doi: 10.1159/000232808.

DOI:10.1159/000232808
PMID:7196388
Abstract

Circulating food antibody levels were measured by ELISA in groups of weanling rabbits fed 320 g/kg diet soya or milk protein. Soya-fed rabbits of milk-fed mothers (and vice versa) showed at least tenfold increase in antibody levels within 3-4 weeks. In contrast, animals fed the same diet as their dams had received in pregnancy and the postnatal period showed little change in antibody levels. These results indicate that contact with a dietary antigen before birth and during the suckling period is important in the induction of tolerance to food proteins in young animals.

摘要

通过酶联免疫吸附测定法(ELISA)测量了喂食含320克/千克大豆或牛奶蛋白日粮的断奶幼兔组的循环食物抗体水平。由喂食牛奶的母兔哺育的喂食大豆的幼兔(反之亦然)在3 - 4周内抗体水平至少增加了十倍。相比之下,喂食与母兔在怀孕和产后所摄入相同日粮的幼兔,其抗体水平几乎没有变化。这些结果表明,在出生前和哺乳期接触饮食抗原对于幼小动物对食物蛋白耐受性的诱导很重要。

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Int Arch Allergy Appl Immunol. 1981;66(1):114-8. doi: 10.1159/000232808.
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