Jones R D, Brenneke C J, Hoss H E, Loney M L
Toxicology Department, Miles, Inc., Stilwell, KS 66085-9104.
Toxicol Lett. 1994 Feb 1;70(2):223-34. doi: 10.1016/0378-4274(94)90166-x.
A five-step electroretinogram protocol was developed for the dog to be used as a painless screening test for ocular effects of drugs or pesticides. Standard conditions of frequency band width, stimulus intensity, dark adaptation time and non-confounding anesthesia method were selected to allow analysis of wave components. The protocol demonstrated an acceptable level of inter-subject variability for compiling an age appropriate database, and for the detection of possible retinal component toxicities in chronic dog studies. This electrophysiologic procedure may serve to corroborate biochemical, clinical and pathology data, in establishing a compound's no-observable-effect-level (NOEL).
已为犬类开发出一种五步视网膜电图检测方案，用作药物或杀虫剂眼部效应的无痛筛查测试。选择了频带宽度、刺激强度、暗适应时间和无干扰麻醉方法的标准条件，以便分析波形成分。该方案在编制适合年龄的数据库以及在慢性犬类研究中检测可能的视网膜成分毒性方面，表现出可接受的受试者间变异性水平。这种电生理程序可用于证实生化、临床和病理学数据，以确定化合物的无可见效应水平（NOEL）。
