回肠肛管吻合术直肠结肠切除术后溃疡性结肠炎患者血清中的抗中性粒细胞胞浆自身抗体

Antineutrophil cytoplasmic auto-antibodies in sera from patients with ulcerative colitis after proctocolectomy with ileo-anal anastomosis.

作者信息

Reumaux D, Colombel J F, Duclos B, Chaussade S, Belaïche J, Jacquot S, Dupas J L, Molis C, Duthilleul P

机构信息

Service d'Hémato-Immunologie, Centre Hospitalier, Valenciennes, France.

出版信息

Adv Exp Med Biol. 1993;336:523-5. doi: 10.1007/978-1-4757-9182-2_95.

DOI:10.1007/978-1-4757-9182-2_95

PMID:8296669

Abstract

Presence of antineutrophil cytoplasmic auto-antibodies (ANCA) in ulcerative colitis could be an epiphenomenon related to colonic inflammation and/or may reflect a primitive disturbance of immune regulation. In this regard, study of ANCA status after the whole colorectal mucosa has been removed could favor one of these two hypothesis. We compared the prevalence of ANCA in a first group of 70 patients with non operated UC and in a second group of 32 patients with UC having had a proctocolectomy with ileoanal anastomosis. Perinuclear ANCA (p-ANCA) were found in 34/70 (49%) of the first group as compared to 11/32 (34%) in the second group (NS). Our results further support that the presence of ANCA in UC reflects an immune disturbance not linked to the presence of the target organ.

摘要

溃疡性结肠炎中抗中性粒细胞胞浆自身抗体（ANCA）的存在可能是一种与结肠炎症相关的附带现象，和/或可能反映了免疫调节的原发性紊乱。在这方面，对全结肠黏膜切除术后ANCA状态的研究可能有助于支持这两种假设中的一种。我们比较了第一组70例未接受手术的溃疡性结肠炎患者和第二组32例接受了直肠结肠切除术并回肠肛管吻合术的溃疡性结肠炎患者中ANCA的患病率。第一组34/70（49%）患者检测到核周型ANCA（p-ANCA），而第二组为11/32（34%）（无显著性差异）。我们的结果进一步支持，溃疡性结肠炎中ANCA的存在反映了一种与靶器官存在无关的免疫紊乱。