Miller A H, Sastry G, Speranza A J, Lawlor B A, Mohs R C, Ryan T M, Gabriel S M, Serby M, Schmeidler J, Davis K L
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
Am J Psychiatry. 1994 Feb;151(2):267-70. doi: 10.1176/ajp.151.2.267.
Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.
