Mersch-Sundermann V, Mochayedi S, Kevekordes S, Kern S, Wintermann F
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
Anticancer Res. 1993 Nov-Dec;13(6A):2037-43.
To determine the DNA damaging properties of unsubstituted and substituted polycyclic hydrocarbons, 61 aromatic and heterocyclic compounds were examined for the induction of the SOS system in E. coli PQ37. PAH such as benzo[ghi]fluoranthene, benzo[j]fluoranthene, benzo[c]phenanthrene, benzo[a]pyrene, chrysene, dibenzo[a,1]pyrene, fluoranthene and triphenylene showed relatively high genotoxicity. With respect to the nitroarenes, the highest genotoxic potencies were exhibited by the dinitropyrenes. The SOS-inducing potency of nitroarenes increased from the bicyclic to the tetracyclic ring system. Additionally, it was seen that any increase in the extent of nitration is paralleled by an increase of genotoxicity. Whereas PAH required metabolic activation by hepatic cytochrome P-450 enzymes, nPAH were direct-acting genotoxicants.
为了确定未取代和取代多环烃的DNA损伤特性，检测了61种芳香族和杂环化合物对大肠杆菌PQ37中SOS系统的诱导作用。多环芳烃如苯并[ghi]荧蒽、苯并[j]荧蒽、苯并[c]菲、苯并[a]芘、 Chrysene、二苯并[a,1]芘、荧蒽和三亚苯表现出相对较高的遗传毒性。对于硝基芳烃，二硝基芘表现出最高的遗传毒性。硝基芳烃的SOS诱导能力从双环到四环环系逐渐增加。此外，可以看出硝化程度的任何增加都伴随着遗传毒性的增加。多环芳烃需要肝脏细胞色素P-450酶进行代谢活化，而硝基多环芳烃是直接作用的遗传毒性剂。
