多环芳烃对大肠杆菌PQ37的遗传毒性。
Genotoxicity of polycyclic aromatic hydrocarbons in Escherichia coli PQ37.
作者信息
Mersch-Sundermann V, Mochayedi S, Kevekordes S
机构信息
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, F.R.G.
出版信息
Mutat Res. 1992 Jan;278(1):1-9. doi: 10.1016/0165-1218(92)90279-9.
In the present investigation, 32 polycyclic aromatic hydrocarbons (PAHs) were tested for genotoxicity in E. coli PQ37 using the standard tube assay of the SOS chromotest. PAHs such as benzo[ghi]fluoranthene, benzo[j]fluoranthene, benzo[a]pyrene, chrysene, dibenzo[a,l]pyrene, fluoranthene and triphenylene exhibited high genotoxicity when incubated in the presence of an exogenous metabolic activation mixture. The results were compared to those obtained with the Salmonella/microsome test.
在本研究中，使用SOS显色试验的标准试管法，对32种多环芳烃（PAHs）在大肠杆菌PQ37中的遗传毒性进行了测试。当在存在外源性代谢活化混合物的情况下孵育时，诸如苯并[ghi]荧蒽、苯并[j]荧蒽、苯并[a]芘、 Chrysene、二苯并[a,l]芘、荧蒽和三亚苯等多环芳烃表现出高遗传毒性。将结果与沙门氏菌/微粒体试验获得的结果进行了比较。
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