Tønnesen H, Møller H, Andersen J R, Jensen E, Juel K
Carl Nielsens Alle 9, Copenhagen, Denmark.
Br J Cancer. 1994 Feb;69(2):327-32. doi: 10.1038/bjc.1994.59.
Data on the association between alcohol abuse and cancer morbidity are scarce in large cohorts of non-hospitalised alcoholic men and women. Of 18,368 alcohol abusers who entered an outpatient clinic in Copenhagen during 1954-87, 18,307 were followed and their cancer incidence was compared with that of the total Danish population. On average the 15,214 men were observed for 12.9 years and the 3,093 women for 9.4 years. The overall morbidity of cancer was increased significantly. Of the men, 1,441 developed cancer [relative risk (RR) = 1.6; 95% confidence interval (CI) = 1.5-1.7], while 182 women did (RR = 1.5; 95% CI 1.3-1.8). Significantly increased incidences were found of cancer in the tongue, mouth, pharynx, oesophagus, liver, larynx, lung and pleura and secondary cancer. The women had significantly increased risk of cervical cancer (RR = 2.0; 95% CI 1.2-3.0). The men developed prostatic cancer significantly more frequently than expected (RR = 1.4; 95% CI 1.2-1.8). The risk of melanomas (RR = 0.5; 95% CI 0.2-0.8) was significantly lower than expected. The relative risks of cancer of the stomach, pancreas, kidney and endocrine system were only slightly increased. The study group did not develop more colonic (RR = 1.0; 95% CI 0.8-1.3) or rectal cancer (RR = 1.0; CI 0.7-1.3) than expected. The risk of breast cancer in women was slightly increased (RR = 1.3; 95% CI 0.9-1.7), but not statistically significant. Thus, the associations between alcohol and cancer of the upper digestive and respiratory tract and the liver are confirmed. In addition, this study indicates an increased occurrence of cancer of the prostate gland, pleura and uterine cervix in alcohol abusers.
在大量未住院的酗酒男性和女性群体中，关于酒精滥用与癌症发病率之间关联的数据稀缺。在1954年至1987年间进入哥本哈根一家门诊诊所的18368名酒精滥用者中，对18307人进行了随访，并将他们的癌症发病率与丹麦总人口的发病率进行了比较。平均而言，15214名男性被观察了12.9年，3093名女性被观察了9.4年。癌症的总体发病率显著增加。男性中有1441人患癌症[相对风险（RR）=1.6；95%置信区间（CI）=1.5 - 1.7]，而女性中有182人患癌症（RR = 1.5；95% CI 1.3 - 1.8）。在舌、口腔、咽、食管、肝、喉、肺和胸膜以及继发性癌症中发现发病率显著增加。女性患宫颈癌的风险显著增加（RR = 2.0；95% CI 1.2 - 3.0）。男性患前列腺癌的频率明显高于预期（RR = 1.4；95% CI 1.2 - 1.8）。黑色素瘤的风险（RR = 0.5；95% CI 0.2 - 0.8）明显低于预期。胃癌、胰腺癌、肾癌和内分泌系统癌症的相对风险仅略有增加。研究组患结肠癌（RR = 1.0；95% CI 0.8 - 1.3）或直肠癌（RR = 1.0；CI 0.7 - 1.3）的情况并未高于预期。女性患乳腺癌的风险略有增加（RR = 1.3；95% CI 0.9 - 1.7），但无统计学意义。因此，酒精与上消化道和呼吸道以及肝脏癌症之间的关联得到了证实。此外，这项研究表明酗酒者中前列腺癌、胸膜癌和子宫颈癌的发病率增加。
