Fonseca W, Alencar A J, Pereira R M, Misago C
Department of Social Medicine, Federal University of Pelotas, R.G. Sul, Brazil.
Clin Dysmorphol. 1993 Jan;2(1):76-80.
This study reports the occurrence of three cases of an unusual congenital malformation of the skull in neonates seen at a pediatric hospital during a five-month interval in Fortaleza, Brazil. The prenatal history focused on the mothers' exposure to drugs during pregnancy. It was found that all mothers had taken misoprostol orally and/or vaginally in the first trimester of pregnancy to induce abortion. Other drugs taken during pregnancy included iron, vitamins and tetanus toxoid. There was no evidence of a family history of malformations, consanguinity or clinical infective illnesses.
本研究报告了在巴西福塔雷萨一家儿科医院五个月期间所见到的三例新生儿罕见先天性颅骨畸形病例。产前病史重点关注母亲孕期的药物接触情况。发现所有母亲在妊娠头三个月口服和/或经阴道使用了米索前列醇以诱导流产。孕期服用的其他药物包括铁剂、维生素和破伤风类毒素。没有畸形家族史、近亲结婚或临床感染性疾病的证据。
