Stathakis N E, Fountas A, Tsianos E
J Clin Pathol. 1981 May;34(5):504-8. doi: 10.1136/jcp.34.5.504.
Plasma fibronectin was determined in 121 normal adults and in 149 patients. Fibronectin levels in normals were strongly influenced by sex and age. The mean value of the protein in cancer patients did not differ from that in normal controls; however, patients with cryofibrinogenaemia or extensive liver metastases had lower values whereas those with obstructive jaundice due to pancreatic carcinoma had higher values than normal controls. Fibronectin levels were greatly increased in patients with primary biliary cirrhosis and moderately elevated in nephrotic syndrome. In patients with severe infection or sepsis, plasma fibronectin did not show a consistent pattern. Patients with overt disseminated intravascular coagulation, irrespective of its cause, had the lowest plasma fibronectin concentrations.
对121名正常成年人和149名患者测定了血浆纤连蛋白。正常人体内的纤连蛋白水平受性别和年龄的影响很大。癌症患者体内该蛋白的平均值与正常对照组无差异；然而，冷纤维蛋白原血症患者或有广泛肝转移的患者其纤连蛋白水平较低，而因胰腺癌导致梗阻性黄疸的患者其纤连蛋白水平高于正常对照组。原发性胆汁性肝硬化患者的纤连蛋白水平大幅升高，肾病综合征患者的纤连蛋白水平中度升高。在严重感染或脓毒症患者中，血浆纤连蛋白未呈现出一致的变化模式。无论病因如何，明显的弥散性血管内凝血患者的血浆纤连蛋白浓度最低。
