Dufaux B, Heine O, Prinz U, Soll C, Rost R
Institute for Cardiology and Sports Medicine, German Sport University Cologne.
Int J Sports Med. 1993 Nov;14(8):468-70. doi: 10.1055/s-2007-1021213.
Eosinophil cationic protein (ECP) has been shown to be a marker of eosinophil granulocyte activation. In 10 healthy young subjects the plasma concentrations of ECP were measured before and after a graded maximal bicycle exercise test. The analyses were carried out 30 min before and immediately before exercise, immediately after exercise and 20 and 45 min later. The post-exercise values were corrected for plasma volume changes which were calculated from hematocrit and hemoglobin values. Immediately post-exercise the ECP increased significantly (p < 0.01) from 1.25 +/- 0.28 at rest to 2.40 +/- 0.59 micrograms/l. Twenty and 45 min later the values normalized and significant differences from the pre-exercise values could no longer be measured. The results provide strong evidence for an activation of eosinophil granulocytes after a short maximal exercise.
嗜酸性粒细胞阳离子蛋白（ECP）已被证明是嗜酸性粒细胞活化的标志物。在10名健康年轻受试者中，在分级最大自行车运动试验前后测量了ECP的血浆浓度。分析在运动前30分钟、运动前即刻、运动后即刻以及运动后20分钟和45分钟进行。运动后的数值针对血浆量变化进行了校正，血浆量变化是根据血细胞比容和血红蛋白值计算得出的。运动后即刻，ECP显著增加（p < 0.01），从静息时的1.25±0.28微克/升升至2.40±0.59微克/升。20分钟和45分钟后，数值恢复正常，与运动前数值不再有显著差异。这些结果为短时间最大运动后嗜酸性粒细胞的活化提供了有力证据。
