Dufaux B, Order U, Liesen H
Institute of Cardiology and Sports Medicine, German University of Sports Sciences, Cologne.
Int J Sports Med. 1991 Jun;12 Suppl 1:S38-42. doi: 10.1055/s-2007-1024748.
In 11 healthy young subjects, the plasma concentrations of the thrombin-antithrombin III complex, fibrinopeptide A, tissue-plasminogen activator, complement fragments C3a and C4a, and histamine were measured before and after a graded maximal bicycle exercise test. The analyses were carried out 30 min before and immediately before exercise, immediately after exercise, and 30 and 60 min later. All post-exercise values were corrected for plasma volume changes, which were calculated from hematocrit and hemoglobin values. Immediately post-exercise, thrombin-antithrombin III, tissue-plasminogen activator, complement fragments C3a and C4a, and histamine were all significantly elevated (p less than 0.01), compared with the pre-exercise values; 30 and 60 min later the values normalized and significant differences from the pre-exercise values could no longer be measured. Fibrinopeptide A did not change significantly after exercise. The present results provide evidence for a simultaneous activation of coagulation, fibrinolysis, and complement system as well as for a release of histamine after a short maximal exercise.
在11名健康的年轻受试者中，在分级最大强度自行车运动试验前后测量了凝血酶 - 抗凝血酶III复合物、纤维蛋白肽A、组织型纤溶酶原激活剂、补体片段C3a和C4a以及组胺的血浆浓度。分析在运动前30分钟、运动前即刻、运动后即刻以及运动后30分钟和60分钟进行。所有运动后的值均根据血浆量变化进行了校正，血浆量变化是根据血细胞比容和血红蛋白值计算得出的。运动后即刻，与运动前的值相比，凝血酶 - 抗凝血酶III、组织型纤溶酶原激活剂、补体片段C3a和C4a以及组胺均显著升高（p小于0.01）；30分钟和60分钟后，这些值恢复正常，与运动前的值不再有显著差异。运动后纤维蛋白肽A没有显著变化。目前的结果为短时间最大强度运动后凝血、纤溶和补体系统的同时激活以及组胺的释放提供了证据。
