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[嗅觉功能与障碍评估]

[Evaluating function and disorders of smell].

作者信息

Herberhold C

机构信息

Universitäts-Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke Bonn.

出版信息

Arch Otorhinolaryngol. 1975;210(1):67-164. doi: 10.1007/BF00453708.

DOI:10.1007/BF00453708
PMID:830101
Abstract

Firstly the review deals with the olfactometry after discussing the olfactory and trigeminal sensitivity of the sense of smell. The term olfactometry will be newly fixed concerning the present problems of odor analysis. Under clinical aspects the methods of subjective olfactometry are discussed and valued. Olfactory tests basing on registering several psychosomatic reflexes (e.g. cardial and/or respiratory frequencies) cannot be described as "objective". Rather methods are objective which record poststimulatory electrophysiological events at different steps of olfactory pathways. The electric response olfactometry representing a cortical evoked so-called twin-potential containing equivalents for trigeminal and olfactory sense activity starts to demonstrate its efficiency. At least a complete test of olfactory function today includes the rhinomanometry for recording ability in nasal odor transport capacity. In the second part are discussed the olfactory disorders with clinical importance. Air borne disorders are confronted with sensorineural, which again are divided in prebulbar, bulbar, and postbulbar ones so far as possible. Respiratory smell disorders depend on nasal ventilation and occur in nasal deformations, in abnormalities of respiratory pathways, in cases of foreign bodies, mucosal inflammations, tumors, intoxications and allergy. Sensorineural olfactory disorders can be attached to age, to malformations or idiopathic defects, inflammations of the olfactory-neural apparatus, head injuries, brain tumors, metabolic or endocrinological diseases. Furthermore often they are accompanied with neurological and psychiatric diseases or professional and chemical intoxications and/or iatrogenic influences. The poor therapeutical possibilities are demonstrated as far as possible. Finally the experting problems in olfactory disorders are delineated, at which the evidence of objective olfactometry can be distincted.

摘要

首先,在讨论嗅觉和三叉神经嗅觉敏感性之后,本文回顾了嗅觉测量法。鉴于目前气味分析的问题,将重新确定嗅觉测量法的定义。从临床角度讨论并评估了主观嗅觉测量法。基于记录多种身心反射(如心率和/或呼吸频率)的嗅觉测试不能被描述为“客观的”。相反,记录嗅觉通路不同阶段刺激后电生理事件的方法才是客观的。代表皮层诱发的所谓双电位的电反应嗅觉测量法,包含三叉神经和嗅觉感觉活动的等效值,开始展现其有效性。如今,至少完整的嗅觉功能测试包括用于记录鼻腔气味传输能力的鼻测压法。第二部分讨论了具有临床重要性的嗅觉障碍。空气传播性障碍与感觉神经性障碍相对,感觉神经性障碍又尽可能地分为球前、球部和球后障碍。呼吸性嗅觉障碍取决于鼻腔通气情况,发生于鼻腔畸形、呼吸道异常、异物、黏膜炎症、肿瘤、中毒和过敏等情况。感觉神经性嗅觉障碍可能与年龄、畸形或特发性缺陷、嗅觉神经装置炎症、头部损伤、脑肿瘤、代谢或内分泌疾病有关。此外,它们常常伴有神经和精神疾病或职业和化学中毒及/或医源性影响。尽可能展示了较差的治疗可能性。最后阐述了嗅觉障碍方面的专家问题,在这些问题中可以区分客观嗅觉测量法的证据。

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Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals.嗅觉功能障碍再探讨:对化学物质所致职业性嗅觉功能障碍的重新评估
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Anosmia, or Cases illustrating the Physiology and Pathology of the Sense of Smell.嗅觉缺失症,或阐释嗅觉生理与病理的病例
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Brain stem reticular formation and activation of the EEG.脑干网状结构与脑电图激活
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Gustoolfactory thresholds in relation to appetite and hunger sensations.与食欲和饥饿感相关的味觉工厂阈值。
J Appl Physiol. 1949 Oct;2(4):217-22. doi: 10.1152/jappl.1949.2.4.217.