Vincent M, Boussaïri E H, Cartier R, Lo M, Sassolas A, Cerutti C, Barrès C, Gustin M P, Cuisinaud G, Samani N J
URA CNRS 1483, Department of Physiology and Clinical Pharmacology, Faculty of Pharmacy, Hôpital Neurologique, Lyon, France.
J Hypertens. 1993 Nov;11(11):1179-85.
A large population of F2 rats, obtained from a cross between male Lyon hypertensive (LH) rats and female Lyon normotensive (LN) rats, was studied in order to assess the relationship between increased body weight, hyperlipidaemia and high blood pressure which characterize LH rats.
Mean arterial pressure (MAP) was recorded in male, conscious, freely moving LH, LN, F1 and F2 rats aged 30 weeks. Plasma total cholesterol, high-density lipoprotein-, low-density lipoprotein- and very low-density lipoprotein-cholesterol, phospholipids, triglycerides, insulin and glucose were measured.
In the F2 cohort it was observed that high MAP was a recessive trait that depends on several genes and was unrelated to body weight. The left ventricular weight, corrected for tibia length, was correlated with MAP. Plasma total and high-density lipoprotein-cholesterol and phospholipids concentrations were lower in the F1 rats than in the LN rats, suggesting an overdominance of the LN alleles. In the F2 rats MAP was related to total, high-density lipoprotein- and low-density lipoprotein-cholesterol. Plasma triglycerides, insulin and the insulin:glucose ratio, which were higher in the LH rats than in the LN rats, were also correlated with MAP in the F2 cohort. Using stepwise multiple regression analysis, MAP remained correlated with plasma total cholesterol, insulin and the insulin:glucose ratio, but not with triglycerides.
Hypertension in LH rats is a recessive trait that is independent of body weight. In addition, the cosegregation of blood pressure with plasma cholesterol and, to a lesser degree, with insulin levels, which was observed in the present study provides the first direct evidence that these phenotypes are associated and are not due simply to genetic drift in the Lyon model.
为了评估体重增加、高脂血症和高血压（这些是里昂高血压（LH）大鼠的特征）之间的关系，对大量由雄性里昂高血压大鼠（LH）与雌性里昂正常血压大鼠（LN）杂交获得的F2大鼠进行了研究。
记录30周龄雄性、清醒、自由活动的LH、LN、F1和F2大鼠的平均动脉压（MAP）。测量血浆总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇、磷脂、甘油三酯、胰岛素和葡萄糖。
在F2队列中观察到，高MAP是一种隐性性状，取决于多个基因，且与体重无关。校正胫骨长度后的左心室重量与MAP相关。F1大鼠的血浆总胆固醇、高密度脂蛋白胆固醇和磷脂浓度低于LN大鼠，提示LN等位基因存在超显性。在F2大鼠中，MAP与总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇相关。LH大鼠的血浆甘油三酯、胰岛素以及胰岛素与葡萄糖的比值高于LN大鼠，在F2队列中这些指标也与MAP相关。使用逐步多元回归分析，MAP仍与血浆总胆固醇、胰岛素以及胰岛素与葡萄糖的比值相关，但与甘油三酯无关。
LH大鼠的高血压是一种与体重无关的隐性性状。此外，本研究中观察到的血压与血浆胆固醇以及在较小程度上与胰岛素水平的共分离，首次直接证明了这些表型是相关的，并非仅仅是由于里昂模型中的遗传漂变。
