Vincent M, Cartier R, Privat P, Benzoni D, Samani N J, Sassard J
URA CNRS 1483, Faculté de Pharmacie, Lyon, France.
J Hypertens. 1996 Apr;14(4):469-74.
To investigate the association of blood pressure with the other major cardiovascular risk factors in a large population of back-cross to Lyon hypertensive (LH) rats.
Mean arterial pressure was recorded in male freely moving Lyon normotensive (LN), LH, F1 and backcross to LH rats aged 30 weeks. Plasma cholesterol, triglycerides, insulin, creatinine, urea, fibrinogen and haematocrit levels, and the insulin: glucose ratio were measured in 31-week-old rats and 24h albuminuria in 6-week-old rats.
Adult LH rats exhibited a significant increase in plasma lipids, insulin, fibrinogen, creatinine, urea and haematocrit levels compared with LN rats. In young LH rats, at an age at which blood pressure is slightly increased, albuminuria was increased to a greater extent than expected from their blood pressure levels. In the adult back-cross to LH rats, only the plasma cholesterol level was associated with blood pressure. Moreover, the plasma cholesterol level was related to fibrinogen and haematocrit levels. Finally, in the same rats, albuminuria developed early in life was positively related to hypercholinesterolaemia measured later in life.
Plasma cholesterol, fibrinogen, haematocrit levels and early albuminuria could act synergistically in the enhancement or the development, or both, of vascular and kidney damage in the LH rat. Most interestingly, the association between plasma cholesterol level and blood pressure indicates that, as in essential hypertension, hypercholesterolaemia is a major phenotype associated with hypertension in the LH rat.
在大量回交至里昂高血压（LH）大鼠的群体中，研究血压与其他主要心血管危险因素之间的关联。
记录30周龄雄性自由活动的里昂正常血压（LN）大鼠、LH大鼠、F1代大鼠以及回交至LH大鼠的平均动脉压。测定31周龄大鼠的血浆胆固醇、甘油三酯、胰岛素、肌酐、尿素、纤维蛋白原和血细胞比容水平，以及胰岛素与葡萄糖比值，并测定6周龄大鼠的24小时蛋白尿。
与LN大鼠相比，成年LH大鼠的血浆脂质、胰岛素、纤维蛋白原、肌酐、尿素和血细胞比容水平显著升高。在年轻的LH大鼠中，在血压略有升高的年龄阶段，蛋白尿的增加程度高于根据其血压水平预期的程度。在成年回交至LH大鼠中，只有血浆胆固醇水平与血压相关。此外，血浆胆固醇水平与纤维蛋白原和血细胞比容水平相关。最后，在同一批大鼠中，生命早期出现的蛋白尿与生命后期测得的高胆固醇血症呈正相关。
血浆胆固醇、纤维蛋白原、血细胞比容水平以及早期蛋白尿可能在LH大鼠血管和肾脏损伤的加重或发生过程中协同起作用，或者两者兼而有之。最有趣的是，血浆胆固醇水平与血压之间的关联表明，与原发性高血压一样，高胆固醇血症是LH大鼠中与高血压相关的主要表型。
