Higgins S E, Fishbaugh J A, Strike D J, Rapuano C J
Insight. 1993 Oct;18(3):14-8.
Corneal thickness was measured in nine positions of nineteen normal eyes with an ultrasonic pachymeter. A standardized protocol was used to examine for intraobserver and interobserver variation, day to day variation, and time of day variation in the measurement of corneal thickness. No statistically significant difference was noted for most points in intraobserver, interobserver, day to day, or different time of day variation measurements. However, it was noted that central measurements of corneal thickness tended to be less variable (more reproducible) than paracentral (p = .0366) and peripheral (.0032) measurements. Paracentral measurements were less variable than peripheral measurements (p = .0323). While this was a small study, 95% confidence intervals were also calculated for each of the nine corneal positions where measurements were performed.
使用超声角膜测厚仪在19只正常眼睛的9个位置测量角膜厚度。采用标准化方案检查角膜厚度测量中的观察者内和观察者间变异、每日变异以及一天中不同时间的变异。在观察者内、观察者间、每日或一天中不同时间的变异测量中，大多数点未发现统计学上的显著差异。然而，值得注意的是，角膜厚度的中央测量值往往比旁中央（p = 0.0366）和周边（p = 0.0032）测量值的变异性更小（更具可重复性）。旁中央测量值的变异性低于周边测量值（p = 0.0323）。虽然这是一项小型研究，但也对进行测量的9个角膜位置中的每一个计算了95%置信区间。
