Whitaker S B, Vigneswaran N, Budnick S D, Waldron C A
Department of Oral Diagnosis and Patient Services, Medical College of Georgia School of Dentistry, Augusta.
J Oral Pathol Med. 1993 Oct;22(9):402-5. doi: 10.1111/j.1600-0714.1993.tb00130.x.
To examine whether giant cell lesions of the jaws (GCL) of varying behavior could be separated histologically, a number of GCL were studied using the AgNOR staining technique for nucleolar organizer regions. The mean AgNOR count of mononuclear cells from recurrent lesions (1.73 +/- 0.15) was slightly higher than that of the aggressive lesions (1.54 +/- 0.21) and much higher than that of the non-aggressive/non-recurrent lesions (1.33 +/- 0.14). Similarly, the mean AgNOR count of the multinucleate giant cells of the recurrent lesions (1.52 +/- 0.14) was slightly higher than that of aggressive lesions (1.34 +/- 0.092) and much higher than that of non-aggressive/non-recurrent lesions (1.26 +/- 0.05). Statistical analysis showed a significant difference between the mean number of AgNORS of recurrent lesions and non-recurrent/non-aggressive ones in both the mononuclear and multinuclear population (p < 0.05).
为了研究不同行为表现的颌骨巨细胞病变（GCL）是否能通过组织学方法区分，我们运用核仁组成区嗜银蛋白（AgNOR）染色技术对一些GCL进行了研究。复发性病变中单核细胞的平均AgNOR计数（1.73±0.15）略高于侵袭性病变（1.54±0.21），且远高于非侵袭性/非复发性病变（1.33±0.14）。同样，复发性病变中多核巨细胞的平均AgNOR计数（1.52±0.14）略高于侵袭性病变（1.34±0.092），且远高于非侵袭性/非复发性病变（1.26±0.05）。统计分析表明，复发性病变与非复发性/非侵袭性病变的单核细胞和多核细胞群体中，AgNORs的平均数量存在显著差异（p<0.05）。
