Nakanishi T, Isobe F, Ogawa Y
Department of Psychiatry, Nagoya University School of Medicine, Japan.
Jpn J Psychiatry Neurol. 1993 Sep;47(3):495-504. doi: 10.1111/j.1440-1819.1993.tb01791.x.
We retrospectively examined 70 depressives, who first visited our outpatient clinic in 1989, agreed to our examination and met the criteria of major depression and melancholic type in DSM-III-R. Forty-nine recovered and 21 had a chronic course of a 2-year duration. Of the items examined in the multivariate analysis, a high total LE score, a long duration prior to entry and a high degree of "Typus melancholicus" greatly contributed to the chronicity in this order of magnitude. Age, severity at entry and sex contributed to it in relatively small degrees and familial loading of depression had almost no effect on the course. The relationship between the degree of "Typus melancholicus" and course of depression was discussed based on data.
我们回顾性地研究了70例抑郁症患者，这些患者于1989年首次就诊于我们的门诊，同意接受检查，并符合DSM-III-R中重度抑郁症和 melancholic 型的标准。49例康复，21例病程长达2年呈慢性病程。在多变量分析中所检查的项目中，高总LE评分、入院前病程长以及“melancholicus型”程度高按此量级顺序对慢性病程有很大影响。年龄、入院时严重程度和性别对慢性病程的影响相对较小，抑郁症的家族负荷对病程几乎没有影响。基于数据讨论了“melancholicus型”程度与抑郁症病程之间的关系。
