绿茶中鞣质对系膜细胞增殖的抑制作用。

Inhibitory effect of tannin in green tea on the proliferation of mesangial cells.

作者信息

Yokozawa T, Oura H, Hattori M, Iwano M, Dohi K, Sakanaka S, Kim M

机构信息

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Nephron. 1993;65(4):596-600. doi: 10.1159/000187570.

DOI:10.1159/000187570

PMID:8302416

Abstract

The effect of green tea tannin on the proliferation of mesangial cells was determined in terms of [3H]thymidine uptake. When green tea tannin was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells markedly. In particular, (-)-epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, exerted an inhibitory effect at a relatively low concentration, suggesting a direct corroboration of the renal effects.

摘要

通过[³H]胸腺嘧啶核苷摄取来测定绿茶单宁对系膜细胞增殖的影响。当将绿茶单宁添加到系膜细胞培养的培养基中时，它能显著抑制系膜细胞的增殖。特别是，(-)-表没食子儿茶素3-O-没食子酸酯，作为绿茶单宁混合物的主要成分，在相对较低的浓度下就发挥了抑制作用，这表明对肾脏的影响得到了直接的确证。